How often is epinephrine given during CPR for a non-shockable rhythm?

• A. Every 1-2 minutes
• B. Every 2-4 minutes
• C. Every 3-5 minutes
• D. Every 5-7 minutes

Answer: (C)

During CPR for a non-shockable rhythm, the goal is to maintain perfusion to the heart and brain while continuing high-quality chest compressions. Epinephrine is given to boost coronary and cerebral perfusion pressure, and the standard practice is to administer 1 mg IV/IO every 3 to 5 minutes and repeat as CPR continues. This 3–5 minute interval fits with the typical CPR cycle, usually about two minutes of compressions before reassessment. Shorter intervals (like every 1–2 minutes) would be too frequent and longer gaps (like every 5–7 minutes) could miss opportunities to improve perfusion. Therefore, the best interval is every 3–5 minutes.